The Ole Miss vs. Wofford game packed the Grove and Vaught-Hemingway Stadium for the first game of the 2016 football season.
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| Sun, Sept. 6 |  | vs Louisville, Nashville | 6:30 PM, ABC |
| Sat, Sep 12 |  | vs Charlotte | 6:45 PM, ESPN2/SECN |
| Sat, Sep 19 |  | LSU | 6:30 PM, ABC |
| Sat, Sep 26 |  | @ Florida | TBD |
| Sat, Oct 10 |  | @ Vanderbilt | TBD |
| Sat, Oct 17 |  | Missouri | TBD |
| Sat, Oct 24 |  | @ Texas | TBD |
| Sat, Oct 31 |  | vs Auburn | TBD |
| Sat, Nov 7 |  | vs Georgia | TBD |
| Sat, Nov 14 |  | @ Oklahoma | TBD |
| Sat, Nov 21 |  | vs Wofford | TBD |
| Sat, Nov 28 |  | vs Mississippi State | 11:00 AM, ABC |
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